The scientific activity of the group is focused on the study of the structure and functions of macromolecular complexes in living cells and in vitro. The main method in our work is the analysis of single particles, which today allows us to obtain reconstructions with near-atomic resolution.

Computer methods of reconstruction of EM images are actively developing, allowing for more and more efficient extraction of information about the structure of molecules at a very low signal-to-noise ratio. Obtaining high-resolution models requires not only a top-class microscope, but also careful data analysis. In addition, strict adherence to sample preparation methods is necessary. 

Structural data are of great importance for the understanding of mechanisms of function and of changes in the activity of protein molecules. The acquired knowledge serves as the basis for molecular modeling, planning of new experiments, and computer design of new medicines.